Symbol Name ID |
Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11 MGI:1100089 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Mandibular osteomyelitis |
Hepatosplenomegaly |
Osteomyelitis |
Disease(s) Associated with TNFSF11 | |||
autosomal recessive osteopetrosis 2 |
Mouse Phenotypes | immune system phenotype |
abnormal thymus cell ratio |
abnormal thymus epithelium morphology |
enlarged thymus medulla |
small thymus medulla |
decreased thymus weight |
thymus hypoplasia |
enlarged spleen |
increased spleen weight |
decreased immature B cell number |
abnormal pro-B cell differentiation |
arrested T cell differentiation |
decreased Langerhans cell number |
decreased mature B cell number |
decreased osteoclast cell number |
increased osteoclast cell number |
abnormal osteoclast morphology |
abnormal osteoclast cell number |
abnormal spleen morphology |
increased spleen red pulp amount |
abnormal spleen B cell follicle morphology |
abnormal spleen marginal zone morphology |
decreased spleen white pulp amount |
abnormal splenic cell ratio |
abnormal immune system morphology |
decreased Peyer's patch number |
small Peyer's patches |
absent mesenteric lymph nodes |
abnormal cervical lymph node morphology |
absent cervical lymph nodes |
absent peripheral lymph nodes |
absent lymph nodes |
abnormal immune system physiology |
decreased interferon-gamma secretion |
decreased interleukin-2 secretion |
decreased interleukin-4 secretion |
decreased interleukin-5 secretion |
decreased interleukin-6 secretion |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
Tnfsf11tles/Tnfsf11tles | |||||||||||||||||||||||||||||||||||||||
Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka | |||||||||||||||||||||||||||||||||||||||
Tnfsf11tm1Pngr/Tnfsf11tm1Pngr | * | ||||||||||||||||||||||||||||||||||||||
Tnfsf11tm1Ywc/Tnfsf11tm1Ywc | |||||||||||||||||||||||||||||||||||||||
Tnfsf11tles/Tnfsf11tm1Pngr | |||||||||||||||||||||||||||||||||||||||
Tnfsf11tm1.2Htaka/Tnfsf11+ | |||||||||||||||||||||||||||||||||||||||
Tnfsf11tm1Ywc/Tnfsf11+ | |||||||||||||||||||||||||||||||||||||||
Tg(APCS-Tnfsf11*)#aKhs/0 | |||||||||||||||||||||||||||||||||||||||
Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob Tg(Dmp1-cre)1Jqfe/0 (conditional) |
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Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob Tg(Prrx1-cre)1Cjt/0 (conditional) |
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Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka Tg(Dmp1-cre)1Jqfe/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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